RHC 80267 ( U-57908 )

产品货号. M21592 CAS No. 83654-05-1

RHC 80267 是 DAGL 的选择性抑制剂（IC50：在犬血小板中为 4 μM）。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥356	有现货
10MG	￥583	有现货
25MG	￥1191	有现货
50MG	￥1993	有现货
100MG	￥2989	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

RHC 80267
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

RHC 80267 是 DAGL 的选择性抑制剂（IC50：在犬血小板中为 4 μM）。
产品描述

RHC 80267 is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)?.
体外实验

The potentiation by RHC 80267 of the relaxation to acetylcholine could be caused by the inhibition of cholinesterase: (1) RHC 80267 does not affect the responses to carbachol, the carbamyl derivative of acetylcholine which only differs from acetylcholine by its resistance to hydrolysis by cholinesterase, and (2) the effect of RHC 80267 is mimicked by the inhibitor of cholinesterase neostigmine, RHC 80267 showing no additional effect in the presence of a maximally effective concentration of neostigmine. The determination of the effect of RHC 80267 on the cholinesterase activity of brain homogenate confirmed that RHC 80267 inhibits this enzyme in the same range of concentrations increasing the relaxation to acetylcholine, namely at 1-10 μM.
体内实验

RHC 80267 (40 μM) enhances contractions induced by U46619 (a thromboxane A2 analog) in human and rat pulmonary arteries (hPAs and rPAs, respectively) and by angiotensin II (ANG II) in rPAs in an endothelium-dependent manner.
同义词

U-57908
通路

Chromatin/Epigenetic
靶点

COX
受体

COX|phosphatidylcholine|DAGL
研究领域

——
适应症

——

化学信息

CAS Number

83654-05-1
分子量

394.51
分子式

C20H34N4O4
纯度

>98% (HPLC)
溶解度

DMSO:25 mg/mL (63.37 mM; Need ultrasonic)
SMILES

O=C(NCCCCCCNC(=O)O\N=C1/CCCCC1)O\N=C1\CCCCC1
化学全称

cyclohexylideneamino N-[6-({[(cyclohexylideneamino)oxy]carbonyl}amino)hexyl]carbamate

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.Suzuki H Kito Y Fukuta H et al. Effects of RHC-80267 an Inhibitor of Diacylglycerol Lipase on Excitation of Circular Smooth Muscle of the Guinea-Pig Gastric Antrum[J]. j smooth muscle res 2003 38(6):153-164.

计算器

浓度计算器

摩尔计算器

分子量计算器

产品手册